Squamous cell carcinoma of the tongue associated with cinnamon gum use: a case report.
作者信息
Westra W H, McMurray J S, Califano J, Flint P W, Corio R L
机构信息
Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287-6417, USA.
出版信息
Head Neck. 1998 Aug;20(5):430-3. doi: 10.1002/(sici)1097-0347(199808)20:5<430::aid-hed12>3.0.co;2-k.
BACKGROUND
Cinnamon aldehydes found in cinnamon-flavored gums can incite mucosal alterations at points of contact with the oral mucosa. These alterations may include inflammation and epithelial proliferation, but as a rule, the changes are reversible and promptly resolve when gum-chewing activity is discontinued.
METHODS
The authors report a case of a 24-year-old woman who developed a squamous cell carcinoma of the tongue following persistent and prolonged exposure to cinnamon-flavored gum.
RESULTS
Several social, clinical, and histopathologic features point to the cinnamon-flavored chewing gum as a possible causal factor in the development of the patient's oral carcinoma.
CONCLUSIONS
Prompt withdrawal of cinnamon products is encouraged in heavy gum chewers who develop cinnamon-related oral lesions. For those lesions which do not promptly resolve upon cinnamon withdrawal, diagnostic biopsy should be considered to exclude the possibility of a squamous cell carcinoma.
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