Erkamp R Q, Wiggins P, Skovoroda A R, Emelianov S Y, O'Donnell M
Biomedical Engineering Department, University of Michigan Ann Arbor 48109-2125, USA.
Ultrason Imaging. 1998 Jan;20(1):17-28. doi: 10.1177/016173469802000102.
Independent measurements of the elastic modulus (Young's modulus) of tissue are necessary step in turning elasticity imaging into a clinical tool. A system capable of measuring the elastic modulus of small tissue samples was developed. The system tolerates the constraints of biological tissue, such as limited sample size (< or = 1.5 cm3) and imperfections in sample geometry. A known deformation is applied to the tissue sample while simultaneously measuring the resulting force. These measurements are then converted to an elastic modulus, where the conversion uses prior calibration of the system with plastisol samples of known Young's modulus. Accurate measurements have been obtained from 10 to 80 kPa, covering a wide range of tissue modulus values. In addition, the performance of the system was further investigated using finite element analysis. Finally, preliminary elasticity measurements on canine kidney samples are presented and discussed.
独立测量组织的弹性模量（杨氏模量）是将弹性成像转变为临床工具的必要步骤。开发了一种能够测量小组织样本弹性模量的系统。该系统能够承受生物组织的限制，如有限的样本大小（≤1.5立方厘米）和样本几何形状的不完美。在对组织样本施加已知变形的同时测量产生的力。然后将这些测量值转换为弹性模量，其中转换过程使用该系统先前对已知杨氏模量的增塑溶胶样本进行的校准。已在10至80千帕的范围内获得了准确测量结果，涵盖了广泛的组织模量值。此外，使用有限元分析进一步研究了该系统的性能。最后，展示并讨论了对犬肾样本的初步弹性测量结果。
