Takagi K, Suzuki F, Barrow R E, Wolf S E, Herndon D N
Shriners Burns Institute--Galveston Unit, Texas 77550, USA.
Ann Surg. 1998 Jul;228(1):106-11. doi: 10.1097/00000658-199807000-00016.
To determine whether growth hormone (GH) influences the production of type 1 T-helper (Th1) and type 2 T-helper (Th2) cytokine responses after burn.
GH has been shown to influence immunoregulation. The authors previously reported improved mortality in burned mice treated with GH after infection with herpesvirus. Other work has shown that impaired immunity after burn was characterized by conversion of Th cell populations from Th1 cells to Th2 cells, suggesting an increased susceptibility of patients with burns to infection.
The production of Th1 and Th2 cytokine from isolated splenic lymphocytes taken from GH-treated burned mice was measured.
At 1 and 11 days after burn, Th1 cytokine production by splenic lymphocytes from burned mice treated with GH was greater than in mice receiving saline. In fact, Th1 cytokine production was greater than that of nonburned mice. In addition, the production of Th2 cytokines was decreased.
Results suggest that the Th1/Th2 response is altered after burn, and this can be reversed with GH. GH, therefore, may improve resistance to infection in patients with burns.
确定生长激素(GH)是否会影响烧伤后1型辅助性T细胞(Th1)和2型辅助性T细胞(Th2)细胞因子反应的产生。
生长激素已被证明会影响免疫调节。作者之前报道,感染疱疹病毒后接受生长激素治疗的烧伤小鼠死亡率有所改善。其他研究表明,烧伤后免疫功能受损的特征是Th细胞群体从Th1细胞转变为Th2细胞,这表明烧伤患者更容易感染。
检测从接受生长激素治疗的烧伤小鼠分离出的脾淋巴细胞中Th1和Th2细胞因子的产生情况。
烧伤后1天和11天,接受生长激素治疗的烧伤小鼠脾淋巴细胞产生的Th1细胞因子比接受生理盐水的小鼠更多。事实上,Th1细胞因子的产生比未烧伤小鼠还要多。此外,Th2细胞因子的产生减少。
结果表明,烧伤后Th1/Th2反应发生改变,而生长激素可以使其逆转。因此,生长激素可能会提高烧伤患者的抗感染能力。