神经生长因子诱导脑膜细胞形成突起：对中枢神经系统损伤后瘢痕形成的影响。
Nerve growth factor induces process formation in meningeal cells: implications for scar formation in the injured CNS.
作者信息
Frisén J, Risling M, Korhonen L, Zirrgiebel U, Johansson C B, Cullheim S, Lindholm D
机构信息
Department of Cell and Molecular Biology, Medical Nobel Institute, S-171 77 Stockholm, Sweden.
出版信息
J Neurosci. 1998 Aug 1;18(15):5714-22. doi: 10.1523/JNEUROSCI.18-15-05714.1998.
Nerve growth factor (NGF) induces the differentiation and supports the survival of subpopulations of neurons in the PNS and CNS. Here we report that meningeal cells in the pia mater express immunoreactivity and mRNA for both known NGF receptors, the low-affinity receptor p75 and the tyrosine kinase receptor trkA. NGF induces rapid tyrosine phosphorylation of trkA in meningeal cells in vitro. NGF does not stimulate proliferation of primary meningeal cells but induces process outgrowth. p75- and trkA-immunoreactive meningeal cells with long processes, resembling NGF-treated cells in vitro, are abundant in the scar tissue that forms at spinal cord lesions in rat and cat. These data suggest that NGF, which is expressed at increased levels in the brain and spinal cord after lesions, may be involved in scar formation in the injured CNS.
神经生长因子（NGF）可诱导周围神经系统（PNS）和中枢神经系统（CNS）中神经元亚群的分化并维持其存活。我们在此报告，软脑膜中的脑膜细胞表达已知的两种NGF受体（低亲和力受体p75和酪氨酸激酶受体trkA）的免疫反应性和mRNA。NGF在体外可诱导脑膜细胞中trkA的快速酪氨酸磷酸化。NGF不会刺激原代脑膜细胞的增殖，但会诱导其长出突起。在大鼠和猫脊髓损伤处形成的瘢痕组织中，具有长突起的p75和trkA免疫反应性脑膜细胞大量存在，类似于体外经NGF处理的细胞。这些数据表明，损伤后在脑和脊髓中表达水平升高的NGF可能参与了受损中枢神经系统中的瘢痕形成。
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