蓝斑介导的对大鼠孤束核化学感受反应的抑制作用是由α2肾上腺素能受体介导的。

Locus coeruleus-mediated inhibition of chemosensory responses in the rat nucleus tractus solitarius is mediated by alpha2-adrenoreceptors.

作者信息

Pérez H, Ruiz S, Laurido C, Hernández A

机构信息

Unit of Neurophysiology and Biophysics, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago.

出版信息

Neurosci Lett. 1998 Jun 12;249(1):37-40. doi: 10.1016/s0304-3940(98)00387-5.

DOI:10.1016/s0304-3940(98)00387-5

PMID:9672383

Abstract

It is known that electrical and L-glutamate stimulation of the locus coeruleus (LC) reduce the multiunit activity evoked in the nucleus of the tractus solitarius (NTS) by cyanoboro-hydride. In the present study, rats anaesthetised with urethane were microinjected with noradrenergic antagonists into the NTS, to test whether the inhibitory effects of LC stimulation on cyanide-evoked discharge in the NTS were mediated by noradrenaline. Microinjection of yohimbine into the NTS (0.2, 0.6, 1.8, 5.4 nmol) induced dose-dependent reduction of the inhibitory effect of LC stimulation on NTS neurones, while prazosin produced no effect. The results indicate that LC-induced inhibition of the cyanide-evoked discharge in the NTS is mediated by endogenous noradrenaline release acting on alpha2-adrenoreceptors.

摘要

已知对蓝斑（LC）进行电刺激和L-谷氨酸刺激可降低硼氢化氰在孤束核（NTS）中诱发的多单位活动。在本研究中，用乌拉坦麻醉的大鼠被微量注射去甲肾上腺素能拮抗剂到NTS中，以测试LC刺激对NTS中氰化物诱发放电的抑制作用是否由去甲肾上腺素介导。向NTS中微量注射育亨宾（0.2、0.6、1.8、5.4纳摩尔）可剂量依赖性地降低LC刺激对NTS神经元的抑制作用，而哌唑嗪则无作用。结果表明，LC诱导的对NTS中氰化物诱发放电的抑制作用是由内源性去甲肾上腺素释放作用于α2-肾上腺素能受体介导的。