Teplova V V, Kudin A P
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Membr Cell Biol. 1998;11(5):641-51.
Effects of cumene hydroperoxide on the Ca(2+)-induced Ca2+ efflux from mitochondria isolated from rat liver and Zaidelja hepatoma were compared. Cumene hydroperoxide at micromolar concentrations (0.3-10 microM) prevented the closing of the permeability transition pore in the inner mitochondrial membrane and, therefore, potentiated the Ca(2+)-induced Ca2+ efflux. This response was 10-100 times greater in hepatoma mitochondria than in rat liver mitochondria. Micromolar concentrations of cumene hydroperoxide induced the death of the hepatoma cells in vitro.
比较了氢过氧化异丙苯对从大鼠肝脏和扎伊德利亚肝癌分离的线粒体中Ca(2+)诱导的Ca2+外流的影响。微摩尔浓度（0.3-10 microM）的氢过氧化异丙苯可防止线粒体内膜通透性转换孔的关闭，因此增强了Ca(2+)诱导的Ca2+外流。这种反应在肝癌线粒体中比在大鼠肝脏线粒体中强10-100倍。微摩尔浓度的氢过氧化异丙苯在体外可诱导肝癌细胞死亡。
