Ortiz P, Santibáñez G, Briones E, Marín V, Palma A
Sección de Gastroenterología, Hospital Guillermo Grant B, Facultad de Medicina, Universidad de Concepción, Chile.
Rev Med Chil. 1998 Mar;126(3):279-83.
Duodenogastric reflux is a normal event that can be deleterious to the esophagic or gastric mucosa, depending on its magnitude, persistence, composition and gastric pH. There is not a definitive method to measure this phenomenon.
To compare the endoscopic visualization of duodenogastric reflux with the quantitation of total bile acids in fasting gastric content (QTBA).
The presence of duodenogastric reflux, defined as the staining of gastric walls with bile during upper gastrointestinal endoscopy, was assessed in 62 patients (26 male), aged 21 to 73 years old. During the week after the endoscopy a sample of fasting gastric content was obtained to measure QTBA, using an enzymatic method.
Median QTBA was 0.205 mumol/gastric residue. Fourteen of 31 patients with QTBA values over the median had endoscopically visible duodenogastric reflux, whereas 1 of 31 with values below the median had visible reflux (p < 0.001).
Endoscopic visualization of duodenogastric reflux is statistically associated to the quantitation of total bile acids in fasting gastric residue.
十二指肠-胃反流是一种正常现象，但其对食管或胃黏膜是否有害取决于反流的程度、持续时间、成分及胃内pH值。目前尚无测定此现象的确定性方法。
比较十二指肠-胃反流的内镜观察结果与空腹胃内容物中总胆汁酸定量（QTBA）情况。
选取62例患者（男性26例），年龄21至73岁，评估其上消化道内镜检查时十二指肠-胃反流的情况，即胃壁胆汁染色情况。内镜检查后一周内，采用酶法获取空腹胃内容物样本以测定QTBA。
QTBA中位数为0.205μmol/胃残余物。QTBA值高于中位数的31例患者中，14例内镜可见十二指肠-胃反流，而QTBA值低于中位数的31例患者中，仅1例可见反流（p<0.001）。
十二指肠-胃反流的内镜观察结果与空腹胃残余物中总胆汁酸定量在统计学上相关。
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