两种形式的8-溴-2',3'-O-异亚丙基腺苷的结构研究。
Structural studies on the two forms of 8-bromo-2',3'-O-isopropylideneadenosine.
作者信息
Fujii S, Fujiwara T, Tomita K
出版信息
Nucleic Acids Res. 1976 Aug;3(8):1985-96. doi: 10.1093/nar/3.8.1985.
Abstract
The crystal and molecular structures of two forms of 8-bromo-2',3'-O-isopropylideneadenosine have been determined by X-ray methods. In one form, the molecular structure has planar conformation in the sugar moiety and no intramolecular hydrogen bond. On the other hand, the molecular structure of the second form has C(2')-endo conformation and an intramolecular hydrogen bond. No stacking interaction between adjacent bases is found in either form, but two modes of the base-pairing hydrogen bond exist in the second form.
摘要
通过X射线方法测定了两种形式的8-溴-2',3'-O-异亚丙基腺苷的晶体和分子结构。在一种形式中，分子结构在糖部分具有平面构象且没有分子内氢键。另一方面，第二种形式的分子结构具有C(2')-内型构象和分子内氢键。在两种形式中均未发现相邻碱基之间的堆积相互作用，但在第二种形式中存在两种碱基配对氢键模式。
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