Goodman S B, Lind M, Song Y, Smith R L
Division of Orthopaedic Surgery, Stanford University Medical Center, CA 94305, USA.
Clin Orthop Relat Res. 1998 Jul(352):25-34.
The biologic effects of wear debris are an important factor limiting the longevity of total joint replacements. In vivo, in vitro, and tissue retrieval studies have underlined a central role for the macrophage in the etiology of loosening and periprosthetic osteolysis. Wear particles from the materials used for total joint replacement activate macrophages to secrete proinflammatory factors. Complex interactions between macrophages and other cells stimulate bone resorption and suppress bone formation at the prosthetic interface. To improve the long term outcome of joint replacements, future research must find innovative approaches to minimize the production and biologic effects of wear debris.
磨损颗粒的生物学效应是限制全关节置换使用寿命的一个重要因素。体内、体外和组织回收研究都强调了巨噬细胞在假体松动和假体周围骨溶解病因学中的核心作用。全关节置换所用材料产生的磨损颗粒激活巨噬细胞分泌促炎因子。巨噬细胞与其他细胞之间的复杂相互作用刺激骨吸收并抑制假体界面处的骨形成。为了改善关节置换的长期效果，未来的研究必须找到创新方法，以尽量减少磨损颗粒的产生及其生物学效应。
