神经调节蛋白受体ErbB2、ErbB3和ErbB4在发育中的小鼠小脑中的表达。

Expression of receptors for neuregulins, ErbB2, ErbB3 and ErbB4, in developing mouse cerebellum.

作者信息

Ozaki M, Kishigami S, Yano R

机构信息

Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Saitama, Japan.

出版信息

Neurosci Res. 1998 Apr;30(4):351-4. doi: 10.1016/s0168-0102(98)00013-3.

DOI:10.1016/s0168-0102(98)00013-3

PMID:9678639

Abstract

We have examined the expression of ErbB2, ErbB3 and ErbB4 in developing mouse cerebellum. ErbB2, ErbB3 and ErbB4 were all expressed in granule cells during cerebellar development. However, the expression pattern for each ErbB receptor changed with the developmental stage. Variations of signal transduction pathway through combinations of these ErbB receptors might have important roles in controlling cerebellar postnatal development.

摘要

我们研究了ErbB2、ErbB3和ErbB4在发育中的小鼠小脑中的表达情况。在小脑发育过程中，颗粒细胞中均表达ErbB2、ErbB3和ErbB4。然而，每种ErbB受体的表达模式随发育阶段而变化。这些ErbB受体组合所形成的信号转导途径的变化，可能在控制小脑出生后的发育中发挥重要作用。