Armstrong R A
Vision Sciences, Aston University, Birmingham, UK.
Dement Geriatr Cogn Disord. 1998 Jul-Aug;9(4):227-38. doi: 10.1159/000017051.
Several types of discrete beta-amyloid (Abeta) deposit or senile plaque have been identified in the brains of individuals with Alzheimer's disease and Down's syndrome. The majority of these plaques can be classified into four morphological types: diffuse, primitive, classic and compact. Two hypotheses have been proposed to account for these plaques. Firstly, that the diffuse, primitive, classic and compact plaques develop in sequence and represent stages in the life history of a single plaque type. Secondly, that the different Abeta plaques develop independently and therefore, unique factors are involved in the formation of each type. To attempt to distinguish between these hypotheses, the morphology, ultrastructure, composition, and spatial distribution in the brain of the four types of plaque were compared. Although some primitive plaques may develop from diffuse plaques, the evidence suggests that a unique combination of factors is involved in the pathogenesis of each plaque type and, therefore, supports the hypothesis that the major types of Abeta plaque develop independently.
在患有阿尔茨海默病和唐氏综合征的个体大脑中，已鉴定出几种类型的离散β-淀粉样蛋白（Aβ）沉积物或老年斑。这些斑块中的大多数可分为四种形态类型：弥漫性、原始性、经典性和致密性。针对这些斑块提出了两种假说。首先，弥漫性、原始性、经典性和致密性斑块按顺序发展，代表单一斑块类型生命历程中的各个阶段。其次，不同的Aβ斑块独立发展，因此，每种类型的形成涉及独特的因素。为了试图区分这些假说，对四种类型斑块在大脑中的形态、超微结构、组成和空间分布进行了比较。虽然一些原始斑块可能由弥漫性斑块发展而来，但证据表明每种斑块类型的发病机制涉及独特的因素组合，因此，支持主要类型的Aβ斑块独立发展这一假说。
