Rad9 comes of age. - Suppr | 超能文献

Rad9 comes of age.

作者信息

Walworth N C

机构信息

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, USA.

出版信息

Science. 1998 Jul 10;281(5374):185-6. doi: 10.1126/science.281.5374.185.

DOI:10.1126/science.281.5374.185

Abstract

摘要

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Rad9 comes of age.

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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.在DNA损伤检查点中，Rad53 FHA结构域与磷酸化的Rad9相关联。

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MEC1-dependent phosphorylation of Rad9p in response to DNA damage.响应DNA损伤时，Rad9p的MEC1依赖性磷酸化。

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Cell cycle progression in the presence of irreparable DNA damage is controlled by a Mec1- and Rad53-dependent checkpoint in budding yeast.在出芽酵母中，存在无法修复的DNA损伤时的细胞周期进程由Mec1和Rad53依赖性检查点控制。

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.酵母细胞周期检查点途径中类ATM激酶MEC1和TEL1对RAD53的调控

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RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.RAD9和DNA聚合酶ε在酿酒酵母中形成平行的传感分支，用于转导DNA损伤检查点信号。

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Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.包含Rad17、Mec3和Ddc1的复合物在酵母DNA损伤检查点途径中的作用。

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Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.chk1和rad53蛋白激酶通过不同机制对DNA损伤检查点进行调控。

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Checkpoints take the next step.检查点迈出下一步。

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Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain.激酶相关蛋白磷酸酶的激酶相互作用结构域，一种磷蛋白结合结构域。

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7821-6. doi: 10.1073/pnas.96.14.7821.