Vogt K, Hahn H
Department of Microbiology, Hospital Virchow and Charité, Humboldt University of Berlin, Germany.
Arzneimittelforschung. 1998 Jun;48(6):694-7.
The minimum inhibitory concentrations of 39 Helicobacter pylori strains against antibiotics (ampicillin, tetracycline, metronidazole), colloidal bismuth subcitrate and proton pump inhibitors were assessed by the agar dilution method. 20.5% of the strains were metronidazole resistent. The comparison of the bactericidal action of omeprazole and lansoprazole in a killing curve assay showed a dose-dependent reduction of viable bacteria after 24 h, lansoprazole being more effective than omeprazole. Under varying pH conditions, the antibacterial activity of lansoprazole was limited to a pH range of 6-7, reducing bacterial numbers up to 4 logarithmical steps within 24 h.
采用琼脂稀释法评估了39株幽门螺杆菌对抗生素（氨苄青霉素、四环素、甲硝唑）、枸橼酸铋钾和质子泵抑制剂的最低抑菌浓度。20.5%的菌株对甲硝唑耐药。在杀菌曲线试验中比较奥美拉唑和兰索拉唑的杀菌作用，结果显示24小时后活菌数量呈剂量依赖性减少，兰索拉唑比奥美拉唑更有效。在不同pH条件下，兰索拉唑的抗菌活性局限于pH 6 - 7范围，24小时内可使细菌数量减少多达4个对数级。
