来自木香的雷诺辛对脂多糖刺激的NRK-52E细胞中CINC-1诱导的抑制作用。
Reynosin from Sassurea lappa as inhibitor on CINC-1 induction in LPS-stimulated NRK-52E cells.
作者信息
Jung J H, Ha J Y, Min K R, Shibata F, Nakagawa H, Kang S S, Chang I M, Kim Y
出版信息
Planta Med. 1998 Jun;64(5):454-5. doi: 10.1055/s-2006-957480.
An inhibitor on CINC-1 (cytokine-induced neutrophil chemoattractant-1) induction in LPS-stimulated rat kidney epithelioid NRK-52E cells was purified from the roots of Sassurea lappa Clarke, a herbal medicine used in Korean traditional prescriptions for gastric intestinal diseases by a variety of column chromatographic procedures. The inhibitor was identified as reynosin, a sesquiterpene lactone isolated and characterized previously from Ambrosia confertiflora DC., and Magnolia grandiflora L. Reynosin exhibited a dose-dependent inhibition on CINC-1 induction in LPS-stimulated NRK-52E cells, where 50% of inhibitory effect was shown at the concentration of about 1 microM.
通过多种柱色谱方法，从用于韩国传统肠胃病处方的草药云木香（Sassurea lappa Clarke）的根中纯化出一种对脂多糖（LPS）刺激的大鼠肾上皮样NRK-52E细胞中细胞因子诱导的中性粒细胞趋化因子-1（CINC-1）诱导具有抑制作用的物质。该抑制剂被鉴定为雷诺辛，一种先前从豚草（Ambrosia confertiflora DC.）和荷花玉兰（Magnolia grandiflora L.）中分离并鉴定的倍半萜内酯。雷诺辛对LPS刺激的NRK-52E细胞中CINC-1的诱导呈剂量依赖性抑制，在约1 microM的浓度下显示出50%的抑制作用。
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