Nagy P, Kiss A, Schnur J, Thorgeirsson S S
1st. Institute of Pathology, Semmelweis Medical University, Budapest, Hungary.
Hepatology. 1998 Aug;28(2):423-9. doi: 10.1002/hep.510280220.
Recent advances have implicated the importance of tumor necrosis factor (TNF) and interleukin 6 (IL-6) in the regulation of liver growth. Therefore, we studied how dexamethasone, a well-known inhibitor of these cytokines, influences the proliferation of different hepatic cell populations. As we expected, dexamethasone pretreatment suppressed the expression of both TNF and IL-6 after partial hepatectomy and significantly reduced the proliferative response of the hepatocytes. Furthermore, the proliferative response of hepatocytes could be rescued by IL-6 administration. Dexamethasone also severely diminished the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but did not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. The differential inhibition of these two morphologically very similar cell types may be used to characterize divergent regulatory mechanisms responsible for the proliferative response of oval cells and adult bile epithelial cells.
最近的研究进展表明肿瘤坏死因子（TNF）和白细胞介素6（IL-6）在肝脏生长调节中具有重要作用。因此，我们研究了地塞米松（一种已知的这些细胞因子抑制剂）如何影响不同肝细胞群体的增殖。正如我们所预期的，部分肝切除术后地塞米松预处理抑制了TNF和IL-6的表达，并显著降低了肝细胞的增殖反应。此外，给予IL-6可挽救肝细胞的增殖反应。地塞米松还严重减少了由2-乙酰氨基芴/部分肝切除术（AAF/PH）方案诱导的卵圆细胞的诱导和扩增，但对胆管结扎刺激的胆管细胞增殖没有任何影响。对这两种形态非常相似的细胞类型的差异抑制可用于表征负责卵圆细胞和成年胆管上皮细胞增殖反应的不同调节机制。
