Abe Y, Kasuya Y
Department of Pharmacology, University of Tsukuba.
Nihon Rinsho. 1998 Jul;56(7):1898-905.
Ten years have passed since endothelin (ET) was identified. The physiological roles of ET isopeptide family and its receptor subtypes have been much clarified by means of pharmacological, biochemical and molecular biological approaches. Especially, analyses with ET receptor blockers and approaches with gene-targeting of ET isopeptides and ET receptor subtypes accelerate the pace of investigations into the true physiological and pathophysiological roles of ET system. Here, we introduce the structure of ET receptor subtypes and their intracellular signal transduction. And, we discuss the physiological role of ET receptor subtypes on basis of information obtained from ET receptor-deficient mice.
自内皮素（ET）被发现以来，已经过去了十年。通过药理学、生物化学和分子生物学方法，ET 异肽家族及其受体亚型的生理作用已得到了很大程度的阐明。特别是，使用 ET 受体阻滞剂的分析以及对 ET 异肽和 ET 受体亚型进行基因靶向的方法加快了对 ET 系统真正生理和病理生理作用的研究步伐。在此，我们介绍 ET 受体亚型的结构及其细胞内信号转导。并且，我们根据从 ET 受体缺陷小鼠获得的信息讨论 ET 受体亚型的生理作用。
