Curschmann J, Greiner R H
Klinik für Radio-Onkologie mit Abteilung für Medizinische Strahlenphysik, Universität Bern, Inselspital.
Ther Umsch. 1998 Jul;55(7):439-41.
Approximately 2% of the Swiss population will develop rectal carcinoma during their lifetime. Most important prognostic factors are TNM category and quality of the surgical procedure. In advanced rectal carcinoma postoperative combined radio-chemotherapy reduces the rate of local recurrence by at least 50 percent and leads to a survival benefit of ca. 10-20%. However, preoperative radiotherapy (+/- chemotherapy) should be the treatment of choice as an adjunct to surgery, especially in cases of deep seated or fixed carcinomas. Intraoperative RT represents a promising modality in situations where a histologically complete excision of the tumor seems impossible.
大约2%的瑞士人口在其一生中会患上直肠癌。最重要的预后因素是TNM分期和手术操作质量。在晚期直肠癌中，术后联合放化疗可将局部复发率降低至少50%，并带来约10%-20%的生存获益。然而，术前放疗（±化疗）作为手术的辅助治疗应是首选，特别是对于深部浸润或固定的肿瘤病例。术中放疗在肿瘤似乎无法通过组织学方法完全切除的情况下是一种有前景的治疗方式。
