[长期接触含二噁英除草剂2,4-D后甲状腺的结构功能变化]
[Structural-functional changes in the thyroid gland after chronic exposure to the dioxin-containing herbicide 2,4-D].
作者信息
Malysheva L N, Zhavoronkov A A
机构信息
Research Institute of Human Morphology, Moscow.
出版信息
Arkh Patol. 1998 May-Jun;60(3):10-3.
PMID:9702293
Abstract
White rats were given by lavage 40% solution of the herbicide 2,4-D (as an amine salt) in doses 1.0 and 0.5 mg/kg during 3 months. Destructive changes in follicles, lymphohistiocytic infiltrates, areas with morphological signs of activation (predominance of small follicles), high alkaline phosphatase and glycoproteins activity in thyrocytes were revealed.
摘要
给白色大鼠灌胃40%的除草剂2,4 - D（胺盐形式），剂量为1.0和0.5毫克/千克，持续3个月。结果显示，甲状腺滤泡出现破坏性变化、淋巴细胞组织细胞浸润、有激活形态学迹象的区域（小滤泡占优势），甲状腺细胞中的碱性磷酸酶和糖蛋白活性较高。
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