Raso D S, Greene W B, Finley J L, Silverman J F
Department of Pathology, East Carolina University School of Medicine, Greenville, USA.
Diagn Cytopathol. 1998 Aug;19(2):116-9. doi: 10.1002/(sici)1097-0339(199808)19:2<116::aid-dc10>3.0.co;2-i.
Liesegang rings are laminated ring-like structures occasionally found in benign cysts and abscesses. They have been confused with parasites (especially eggs), algae, calcifications, and psammoma bodies. We examined Liesegang rings from fine-needle aspiration (FNA) biopsies of a benign cyst of the breast and a complex renal cyst. Liesegang rings were best observed with Papanicolaou, hematoxylin-eosin, Masson's trichrome, acid-fast (AFB), and Gram stains, which accentuate the concentrically laminated morphology. An amorphous electron-dense core and fibrillary lucent concentric rings were seen with transmission electron microscopy with no significant energy peaks by electron probe microanalysis or distinct diffraction patterns by X-ray diffraction. This investigation indicates that Liesegang rings are composed of organic substances most likely formed by periodic precipitation from a supersaturated solution within cystic fluid. Awareness of the Liesegang phenomenon within cystic lesions will decrease the possibility of erroneous misdiagnosis as another type of pathologic process.
李塞冈环是偶尔在良性囊肿和脓肿中发现的分层环状结构。它们曾被与寄生虫（尤其是虫卵）、藻类、钙化及砂粒体混淆。我们检查了来自乳腺良性囊肿和复杂性肾囊肿细针穿刺（FNA）活检的李塞冈环。用巴氏染色、苏木精-伊红染色、马松三色染色、抗酸（AFB）染色和革兰染色能最好地观察到李塞冈环，这些染色突出了同心分层的形态。透射电子显微镜下可见无定形电子致密核心和纤维状透明同心环，电子探针微量分析未发现明显能量峰，X射线衍射也未发现明显衍射图案。这项研究表明，李塞冈环由有机物质组成，很可能是由囊液中超饱和溶液的周期性沉淀形成的。认识到囊性病变中的李塞冈现象将减少误诊为其他类型病理过程的可能性。
