Xiang Z, Huguenard J R, Prince D A
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA 94305, USA.
Science. 1998 Aug 14;281(5379):985-8. doi: 10.1126/science.281.5379.985.
Differential actions of acetylcholine on the excitability of two subtypes of interneurons in layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) cells through nicotinic receptors, whereas it elicited hyperpolarization in fast spiking (FS) cells through muscarinic receptors. Axons of LTS cells were mainly distributed vertically to upper layers, and those of FS cells were primarily confined to layer V. Thus, cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibition, and change the direction of information flow within cortical circuits.
研究了乙酰胆碱对大鼠视觉皮层V层中两种中间神经元亚型兴奋性的不同作用。乙酰胆碱通过烟碱受体使低阈值尖峰（LTS）细胞兴奋，而通过毒蕈碱受体在快速放电（FS）细胞中引起超极化。LTS细胞的轴突主要垂直分布到上层，而FS细胞的轴突主要局限于V层。因此，皮层胆碱能激活可能会减少某些形式的层内抑制，促进柱内抑制，并改变皮层回路内的信息流方向。
