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亚硒酸钠用于预防继发性淋巴水肿中的丹毒。

Sodium selenite as prophylaxis against erysipelas in secondary lymphedema.

作者信息

Kasseroller R

机构信息

Wittlinger's Therapy Center, Walchsee, Austria.

出版信息

Anticancer Res. 1998 May-Jun;18(3C):2227-30.

PMID:9703790
Abstract

In a randomised, double-blind study, the efficacy of sodium selenite application in combination with physical therapy to relieve congestion was investigated in a cohort of 60 cancer patients with secondary lymphedema, with special reference to the development of the incidence of erysipelas. All of the patients investigated in this study had erysipelas infection of the skin. Selenium was administered in pharmacological doses. The duration of physical therapy was three weeks. Patients were under observation for a further three months. The incidence of erysipelas among our patients was 11%. During the three-week period of intensive treatment, there was not a single case of erysipelas in the treatment group, whereas there was one single case in the placebo group. In the follow-up period (3 months), once again there was not a single case of erysipelas in the treatment group, but 50% of the patients in the placebo group exhibited erysipelas. In spite of higher doses, the selenium level did not rise above normal values. Patients under long-term antibiotic therapy suffered no relapse when the antibiotic therapy was stopped and instead, selenium was administered. It could be shown, in addition, that by administration of a single high-dose of sodium selenite, inflammation could be immediately brought under control.

摘要

在一项随机双盲研究中,对60例患有继发性淋巴水肿的癌症患者组成的队列进行了研究,探讨亚硒酸钠联合物理治疗缓解充血的疗效,特别关注丹毒发病率的变化。本研究中所有接受调查的患者均有皮肤丹毒感染。给予患者药理学剂量的硒。物理治疗为期三周。患者进一步观察三个月。我们患者中的丹毒发病率为11%。在强化治疗的三周期间,治疗组未出现一例丹毒病例,而安慰剂组有一例。在随访期(3个月),治疗组再次未出现一例丹毒病例,但安慰剂组50%的患者出现丹毒。尽管剂量较高,但硒水平未超过正常值。长期接受抗生素治疗的患者在停止抗生素治疗并改用硒治疗后未复发。此外,还可以证明,通过单次高剂量给予亚硒酸钠,炎症可立即得到控制。

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