Tsuji Y, Hamada H, Hashimoto M, Kujime J, Yamagami H, Tomita I, Kimura J, Katsuki Y, Ohira S
Dept. of Surgery, Nikko Memorial Hospital.
Gan To Kagaku Ryoho. 1998 Jul;25(9):1382-4.
We treated 18 cases with intra-hepatic arterial infusion chemotherapy after resection of hepatic metastasis from colorectal cancer (June 1991-September 1997). Eight cases were H1, 7 were H2, and 3 were H3. Hepatic lobectomy was done in 3 cases, lobectomy + partial resection in 2 cases, and partial resection in 13 cases. All cases received high-dose intermittent 5-FU infusion (WHF = 5-FU 1,000 mg/m2/5 hrs/w) on an outpatient basis. The total frequency of WHF was 4-54 times (average 29), and total 5-FU doses ranged from 6.0 to 81.0 g (average 40 g). The 1- and 5-year cumulative survival rates were 100% and 77.5% in all patients 100% and 87.5% in H1 group and 100% and 64.3% in H2 + H3 group, respectively. There was no significant difference of survival between the H1 and H1 + H3 groups. The 1- and 5-year recurrence rates in residual liver were 5.9% and 14.4%, respectively. One of 2 cases with residual liver recurrence was resected for metastasis again, and the patient is now in a disease-free state. WHF after resection of hepatic metastasis from colorectal cancer has a preventive effect for their survival, not only in H1 group but also in H2 + H3 group.
我们对18例结直肠癌肝转移切除术后患者进行了肝动脉内灌注化疗（1991年6月至1997年9月）。其中H1期8例，H2期7例，H3期3例。3例行肝叶切除术，2例行肝叶切除+部分切除术，13例行部分切除术。所有患者门诊接受高剂量间歇5-氟尿嘧啶灌注（WHF = 5-氟尿嘧啶1000mg/m²/5小时/周）。WHF总次数为4 - 54次（平均29次），5-氟尿嘧啶总剂量为6.0至81.0g（平均40g）。所有患者1年和5年累积生存率分别为100%和77.5%，H1组为100%和87.5%，H2 + H3组为100%和64.3%。H1组与H1 + H3组生存率无显著差异。残余肝1年和5年复发率分别为5.9%和14.4%。2例残余肝复发患者中有1例再次行转移灶切除，目前处于无病状态。结直肠癌肝转移切除术后的WHF对患者生存有预防作用，不仅在H1组，在H2 + H3组也如此。
