Martin W J, Malmberg A B, Basbaum A I
Department of Anatomy, University of California at San Francisco 94143-0452, USA.
Curr Biol. 1998 Jul 16;8(15):R525-7. doi: 10.1016/s0960-9822(07)00338-7.
Tissue or nerve injury can dramatically alter the transmission of sensory stimuli by spinal cord neurons, so that a light touch produces pain. The discovery that peptide products of prepronociceptin processing either facilitate or inhibit these mechanisms suggests novel approaches to treating these conditions.
组织或神经损伤可显著改变脊髓神经元对感觉刺激的传递,以至于轻微触摸也会产生疼痛。痛敏肽原加工产生的肽产物既能促进也能抑制这些机制,这一发现为治疗这些病症提供了新方法。