Chiba M, Fukushima T, Koganei K, Nakamura N, Masamune O
First Dept. of Internal Medicine, Akita University School of Medicine, Akita City, Japan.
Scand J Gastroenterol. 1998 Jul;33(7):778-82. doi: 10.1080/00365529850171765.
A case of ulcerative colitis in which the presence of Listeria monocytogenes was confirmed in the resected colon with polymerase chain reaction and subsequent Southern blot analysis and immunohistochemistry using antibody against Listeria is presented. The patient developed ulcerative colitis at the age of 59 years. Prednisolone, 50 mg/day, was given for severe ulcerative colitis. Later the disease became fulminating, indicating colectomy 4 months after the onset. Multiple sealed colonic perforations were observed. Numerous L. monocytogenes were found at the site of perforation, in fissures, and in cracks in the submucosa. This case indicates the possibility that L. monocytogenes contributes to the exacerbation of colitis to fulminating and colonic perforation.
本文报告一例溃疡性结肠炎患者，通过聚合酶链反应、随后的Southern印迹分析以及使用抗李斯特菌抗体的免疫组织化学方法，在切除的结肠中证实了单核细胞增生李斯特菌的存在。该患者59岁时患上溃疡性结肠炎。因严重溃疡性结肠炎给予泼尼松龙50mg/天治疗。后来病情发展为暴发性，发病4个月后行结肠切除术。观察到多处结肠密封穿孔。在穿孔部位、裂隙以及黏膜下层的裂缝中发现了大量单核细胞增生李斯特菌。该病例表明单核细胞增生李斯特菌可能促使结肠炎恶化为暴发性并导致结肠穿孔。
