Vestbo J, Prescott E, Lange P, Schnohr P, Jensen G
Copenhagen City Heart Study, Epidemiological Research Unit, Rigshospitalet, Copenhagen, Denmark.
Respir Med. 1998 May;92(5):772-6. doi: 10.1016/s0954-6111(98)90011-7.
To examine survival after admission due to chronic obstructive pulmonary disease (COPD) in a population sample over a time span of 15 years.
Linkage between a prospective population cohort and register information on hospitalization and mortality.
The Copenhagen City Heart Study (CCHS).
A total of 267 men and 220 women who had participated in the CCHS and who were hospitalized with a discharge diagnosis of COPD (ICD-8 491-2).
The crude 5-yr survival rate after a COPD admission was 45% (37% for men and 52% for women). Mortality risk increased with age and with decreasing forced expiratory volume in 1 s (FEV1)% predicted; for subjects with an FEV1 < or = 40% at the CCHS survey, 5-yr survival after subsequent hospitalization was only 28%. Smoking and presence of chronic mucus hypersecretion at the examination in CCHS were not strongly associated with prognosis. Survival after admission due to COPD did not change significantly over time.
Compared to previous studies of COPD patients, the present study indicates that prognosis after hospital admission remains virtually unchanged over the last decades. FEV1 is still the strongest predictor of survival in this patient group.
在15年的时间跨度内，对人群样本中因慢性阻塞性肺疾病（COPD）入院后的生存率进行研究。
前瞻性人群队列与住院和死亡率登记信息之间的关联研究。
哥本哈根城市心脏研究（CCHS）。
共有267名男性和220名女性参与了CCHS，并因COPD（国际疾病分类第八版491-2）出院诊断而住院。
COPD入院后的5年粗生存率为45%（男性为37%，女性为52%）。死亡风险随年龄增加以及预计第1秒用力呼气量（FEV1）%的降低而增加；在CCHS调查中FEV1≤40%的受试者，随后住院后的5年生存率仅为28%。CCHS检查时的吸烟情况和慢性黏液高分泌的存在与预后无强烈关联。因COPD入院后的生存率随时间无显著变化。
与之前对COPD患者的研究相比，本研究表明在过去几十年中，入院后的预后基本保持不变。FEV1仍然是该患者群体生存的最强预测因素。
