人软骨素6 - 硫酸转移酶的分子克隆与表达
Molecular cloning and expression of human chondroitin 6-sulfotransferase.
作者信息
Fukuta M, Kobayashi Y, Uchimura K, Kimata K, Habuchi O
机构信息
Department of Life Science, Aichi University of Education, Japan.
出版信息
Biochim Biophys Acta. 1998 Jul 30;1399(1):57-61. doi: 10.1016/s0167-4781(98)00089-x.
Using cDNA of chick chondroitin 6-sulfotransferase (C6ST), human C6ST cDNA has been isolated. The amino acid sequence of human C6ST displayed 74% identity to chick C6ST. The major difference in amino acid sequence between chick C6ST and human C6ST was the presence of a unique hydrophilic domain in human C6ST. A 7.8-kb message of C6ST was expressed ubiquitously in various human adult tissues, indicating a rather diverse function of C6ST.
利用鸡软骨素6 - 硫酸转移酶（C6ST）的互补DNA（cDNA），已分离出人类C6ST cDNA。人类C6ST的氨基酸序列与鸡C6ST有74%的同一性。鸡C6ST和人类C6ST在氨基酸序列上的主要差异在于人类C6ST存在一个独特的亲水区。C6ST的一个7.8千碱基的信使核糖核酸（mRNA）在各种人类成年组织中普遍表达，表明C6ST具有相当多样的功能。
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