Nandedkar T D, Wadia P
Institute for Research in Reproduction, Mumbai, India.
Indian J Exp Biol. 1998 May;36(5):433-6.
Infertility and ovarian disorders may occur not only due to imbalance in the steroid hormones but also due to the alteration in the immune function. A number of autoimmune disorders of the ovary, such as polycystic ovarian syndrome, premature ovarian failure and autoimmune oophoritis, have been documented. Both the cell mediated and humoral immune responses play an important role in these disorders. Cytokines secreted by the immune cells could have an adverse effect on ovarian steroidogenesis whereas the production of pathogenic T cells could lead to autoimmune disease of the ovary. Autoantibodies to granulosa and theca cells as well as zona pellucida of the oocyte have also been documented in women indicating that autoimmunity plays an important role in infertility. Thus the endocrine and the immune system work hand in hand to regulate ovarian function.
不孕和卵巢疾病不仅可能由于甾体激素失衡引起，还可能由于免疫功能改变所致。已记录了多种卵巢自身免疫性疾病，如多囊卵巢综合征、卵巢早衰和自身免疫性卵巢炎。细胞介导的免疫反应和体液免疫反应在这些疾病中均起重要作用。免疫细胞分泌的细胞因子可能对卵巢甾体激素生成产生不利影响，而致病性T细胞的产生可能导致卵巢自身免疫性疾病。在女性中也已记录到针对颗粒细胞、卵泡膜细胞以及卵母细胞透明带的自身抗体，这表明自身免疫在不孕中起重要作用。因此，内分泌系统和免疫系统携手合作以调节卵巢功能。
