O'Dell S D, Day I N
Wessex Human Genetics Institute, Southampton University Hospitals NHS Trust, UK. s.d.o'
Int J Biochem Cell Biol. 1998 Jul;30(7):767-71. doi: 10.1016/s1357-2725(98)00048-x.
Insulin-like growth factor II (IGF-II) plays a key role in mammalian growth, influencing foetal cell division and differentiation and possibly metabolic regulation. The mature 67 amino acid peptide shares sequence homology with both insulin and IGF-I. The liver is the main endocrine source of IGFs, but autocrine/paracrine activity is found in most tissues. The type 1 receptor mediates most of the biological effects of IGF-I and IGF-II; the type 2 receptor is involved with IGF-II degradation. Binding proteins may both localise IGFs to the receptors and regulate their activities. The IGF2 gene is maternally imprinted in mouse and human. Relaxation of IGF2 imprinting occurs in the Beckwith-Wiedemann syndrome of somatic overgrowth, sporadic Wilms' tumour and a number of other cancers. In the general adult population, the IGF2-INS gene cluster may also influence body weight, in which case IGF-II function could become a target for therapeutic intervention in obesity.
胰岛素样生长因子II（IGF-II）在哺乳动物生长中起关键作用，影响胎儿细胞分裂和分化，并可能参与代谢调节。成熟的67个氨基酸肽与胰岛素和IGF-I均具有序列同源性。肝脏是IGFs的主要内分泌来源，但在大多数组织中也存在自分泌/旁分泌活性。1型受体介导IGF-I和IGF-II的大多数生物学效应；2型受体参与IGF-II的降解。结合蛋白可将IGFs定位到受体并调节其活性。IGF2基因在小鼠和人类中是母系印记的。IGF2印记的松弛发生在躯体过度生长的贝克威思-维德曼综合征、散发性威尔姆斯瘤和其他一些癌症中。在一般成年人群中，IGF2-INS基因簇也可能影响体重，在这种情况下，IGF-II功能可能成为肥胖治疗干预的靶点。
