Bernasconi P, Cavigliano P M, Genini E, Castagnola C, Malcovati L, Calatroni S, Caresana M, Boni M, Alessandrino E P, Astori C, Corso A, Bernasconi C
Istituto di Ematologia, Università di Pavia, Italy.
Cancer Genet Cytogenet. 1998 Sep;105(2):182-6. doi: 10.1016/s0165-4608(97)00474-3.
Complete or partial monosomy for the long arms of chromosomes 5 or 7 or both is frequently observed in therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia. Sporadic cases have been reported in which partial monosomy is due to unbalanced translocations. The patient described herein carries one such rearrangement. 46,XY,t(1;2) (q32;p23),del(5)(q13),der(7)(5qter-->5q22::7p15-->7 q21:),del(12)(p12), resulting in partial monosomy for the long arms of chromosomes 5 and 7 and in partial monosomy for the short arm of chromosome 7.
在治疗相关的骨髓增生异常综合征和急性非淋巴细胞白血病中，经常观察到5号或7号染色体长臂的完全或部分单体性，或两者皆有。已有散发病例报道，其中部分单体性是由不平衡易位所致。本文所述患者携带一种此类重排。46，XY，t(1;2)(q32;p23)，del(5)(q13)，der(7)(5qter→5q22::7p15→7q21)，del(12)(p12)，导致5号和7号染色体长臂部分单体性以及7号染色体短臂部分单体性。
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