安非他酮和地昔帕明可增加大鼠脑海马腹侧被盖区/黑质中多巴胺转运体的信使核糖核酸表达。
Bupropion and desipramine increase dopamine transporter mRNA expression in the ventral tegmental area/substantia nigra of rat brain.
作者信息
Petrie E C, Veith R C, Szot P
机构信息
Mental Health Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):845-56. doi: 10.1016/s0278-5846(98)00044-x.
PMID:9723124
Abstract
- Regulation of dopamine transporter (DAT) mRNA was studied in rats treated with the DAT blocker bupropion (BUP; 15 or 30 mg/kg tid x 2d), the norepinephrine transporter blocker desipramine (DMI; 10 mg/kg/d x 2d), or saline. 2. mRNA expression was assessed via in situ hybridization histochemistry. 3. BUP and DMI both increased DAT mRNA expression in the ventral tegmental area/substantia nigra. 4. These findings suggest that DAT mRNA expression in the brain may be regulated by both noradrenergic and dopaminergic mechanisms.
摘要
- 在接受多巴胺转运体（DAT）阻滞剂安非他酮（BUP；15或30毫克/千克，每日三次，共2天）、去甲肾上腺素转运体阻滞剂地昔帕明（DMI；10毫克/千克/天，共2天）或生理盐水处理的大鼠中，研究了DAT mRNA的调节情况。2. 通过原位杂交组织化学评估mRNA表达。3. BUP和DMI均增加了腹侧被盖区/黑质中的DAT mRNA表达。4. 这些发现表明，脑中的DAT mRNA表达可能受去甲肾上腺素能和多巴胺能机制的调节。
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