Rüter A, Smeds S, Lennquist S
Department of Gastroenterology and Endocrinology, University Hospital, Linköping, Sweden.
Eur J Surg. 1998 Sep;164(9):665-71. doi: 10.1080/110241598750005543.
To study the clinical relevance of measurements of serum thyroglobulin in patients undergoing total thyroidectomy for well differentiated thyroid cancer.
Prospective study.
University hospital, Sweden.
194 patients operated on for well differentiated thyroid cancer from 1 January 1978 to 31 December 1992.
All patients underwent total thyroidectomy by a standard technique, and were prospectively followed up at regular intervals by clinical examination and measurement of the serum thyroglobulin concentration.
Six patients whose thyroglobulin concentrations after operation were low or undetectable had gradual increases leading to detection of recurrences that could be treated successfully. Six patients had gradual increases without detectable recurrences. In 12 patients thyroglobulin concentrations remained high after operation with no signs of thyroid tissue remaining, which we interpreted as persistence of the disease. No recurrence was found without an appreciable rise in the thyroglobulin concentration. Thyroglobulin antibodies were found in 81 (42%).
Measurement of the serum thyroglobulin concentration is a valuable addition to the follow up of patients operated on for highly differentiated thyroid cancer. In many cases it is the first sign of recurrent disease, thereby facilitating early and successful treatment.
研究在接受全甲状腺切除术治疗高分化甲状腺癌的患者中，血清甲状腺球蛋白测量的临床相关性。
前瞻性研究。
瑞典大学医院。
1978年1月1日至1992年12月31日期间因高分化甲状腺癌接受手术的194例患者。
所有患者均采用标准技术接受全甲状腺切除术，并通过临床检查和血清甲状腺球蛋白浓度测量进行定期前瞻性随访。
6例术后甲状腺球蛋白浓度低或检测不到的患者，其浓度逐渐升高，随后检测到可成功治疗的复发。6例患者甲状腺球蛋白浓度逐渐升高，但未检测到复发。12例患者术后甲状腺球蛋白浓度持续升高，且无甲状腺组织残留迹象，我们将其解释为疾病持续存在。甲状腺球蛋白浓度无明显升高则未发现复发。81例（42%）患者检测到甲状腺球蛋白抗体。
血清甲状腺球蛋白浓度测量是对接受高分化甲状腺癌手术患者进行随访的一项有价值的补充。在许多情况下，它是疾病复发的首个迹象，从而有助于早期成功治疗。
Zotero 插件