Small G W, Leiter F
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Veterans Affairs Medical Center, USA.
J Clin Psychiatry. 1998;59 Suppl 11:4-7.
Although many clinicians consider neuroimaging studies as optional for the differential diagnosis of dementia, clinical experience suggests that they can improve diagnostic accuracy. Data are limited, however, on sensitivity, specificity, and cost-effectiveness of various neuroimaging techniques. The author reviews advantages and disadvantages of neuroimaging techniques for the differential diagnosis of dementia and describes strategies used for early detection of Alzheimer's disease, including combining positron emission tomography scanning with genetic risk assessment. Such approaches could provide a means for in vivo therapeutic monitoring of brain function during experimental antidementia treatment trials.
尽管许多临床医生认为神经影像学研究对于痴呆的鉴别诊断是可选择的，但临床经验表明它们可以提高诊断准确性。然而，关于各种神经影像学技术的敏感性、特异性和成本效益的数据有限。作者回顾了用于痴呆鉴别诊断的神经影像学技术的优缺点，并描述了用于早期检测阿尔茨海默病的策略，包括将正电子发射断层扫描与遗传风险评估相结合。这些方法可为实验性抗痴呆治疗试验期间脑功能的体内治疗监测提供一种手段。
