Peters C, Ladenstein R, Minkov M, Pötschger U, Gadner H, Cornish J, Dini G, Klingebiel T, Locatelli F, Vossen J, Niethammer D
St Anna Children's Hospital, Vienna, Austria.
Bone Marrow Transplant. 1998 Sep;22(5):431-7. doi: 10.1038/sj.bmt.1701365.
To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT mainly in children. Fifty-five centres from 19 countries responded. Forty centres (75%) started their transplantation activities between 1980 and 1992. Median number of transplants/centre was 95 (range 8-400). Median number of transplants/centre/year was 18 (range 5-85). On average, there was one physician responsible for seven SCT/year while one nurse was involved for a median of 1.7 SCT/year. Median four rooms/centre (range 1-17) were available for paediatric SCT. The most common isolation facilities were rooms with high efficiency particulate air filtration (HEPA). Eighty-two percent (45/55) of the centres performed allogeneic as well as autologous SCT, while 5% (three centres) offered exclusively allogeneic SCT and 13% (seven centres) used only autologous stem cell rescue. Stem cell source for allogeneic SCT was bone marrow in 87%, peripheral blood (PB) in 10% and umbilical cord blood in 3%. Donors were HLA matched related in 57%, mismatched related in 13%, and matched unrelated in 30% of allogeneic SCT. PB was the most commonly used stem cell source for autologous SCT (48%), followed by BM (41%) and the two together (11%). Data analysis revealed substantial differences in protective care, stem cell processing and transplantation procedures within the centres, irrespective of the country, centre size and transplant type.
为确定主要治疗儿科患者的中心目前的干细胞移植（SCT）方法，向欧洲血液与骨髓移植协会（EBMT）登记处所知的67个主要开展儿童SCT的中心发送了一份调查问卷。来自19个国家的55个中心进行了回复。40个中心（75%）在1980年至1992年期间开始其移植活动。每个中心移植的中位数为95次（范围8 - 400次）。每个中心每年移植的中位数为18次（范围5 - 85次）。平均而言，一名医生负责每年7例SCT，而一名护士参与的SCT中位数为每年1.7例。每个中心有用于儿科SCT的中位数为4间病房（范围1 - 17间）。最常见的隔离设施是配备高效空气微粒过滤器（HEPA）的房间。82%（45/55）的中心进行异基因和自体SCT，而5%（三个中心）仅提供异基因SCT，13%（七个中心）仅使用自体干细胞救援。异基因SCT的干细胞来源中，87%为骨髓，10%为外周血（PB），3%为脐带血。在异基因SCT中，57%的供者为HLA匹配的亲属，13%为不匹配的亲属，30%为匹配的非亲属。PB是自体SCT最常用的干细胞来源（48%），其次是骨髓（41%），两者一起占（11%）。数据分析显示，无论国家、中心规模和移植类型如何，各中心在保护性护理、干细胞处理和移植程序方面存在显著差异。
