通过DNA免疫保护小鼠免受致死性柯萨奇病毒B3感染。
Protection of mice against lethal coxsackievirus B3 infection by using DNA immunization.
作者信息
Henke A, Wagner E, Whitton J L, Zell R, Stelzner A
机构信息
Institute of Virology, Medical Center, Friedrich Schiller University, 07745 Jena, Germany.
出版信息
J Virol. 1998 Oct;72(10):8327-31. doi: 10.1128/JVI.72.10.8327-8331.1998.
Abstract
Vaccination with DNA and recombinant vaccinia viruses (rec.VV) has been studied with the coxsackievirus B3 (CVB3) model system. Plasmids encoding all structural proteins of CVB3, when injected intramuscularly, induced only low levels of virus-specific antibodies. However, DNA vaccination with the major structural protein VP1 protected 72.2% of mice from lethal challenge, whereas VP1 expressed by rec.VV was much less efficient.
摘要
已利用柯萨奇病毒B3（CVB3）模型系统对DNA疫苗和重组痘苗病毒（rec.VV）疫苗接种进行了研究。编码CVB3所有结构蛋白的质粒经肌肉注射后，仅诱导产生低水平的病毒特异性抗体。然而，用主要结构蛋白VP1进行DNA疫苗接种可使72.2%的小鼠免受致死性攻击，而rec.VV表达的VP1效率则低得多。
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本文引用的文献
1
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Vaccine. 1997 Apr;15(5):553-60. doi: 10.1016/s0264-410x(97)00213-2.
2
A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.柯萨奇病毒B3伍德拉夫变种感染性cDNA的VP2 puff区域突变减弱了其心肌炎性表型。
J Virol. 1996 Nov;70(11):7811-8. doi: 10.1128/JVI.70.11.7811-7818.1996.
3
High yield production of an inactivated coxsackie B3 adjuvant vaccine with protective effect against experimental myocarditis.高效生产具有预防实验性心肌炎保护作用的灭活柯萨奇B3佐剂疫苗。
Scand J Infect Dis Suppl. 1993;88:103-8.
4
DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations.DNA疫苗：通过肠胃外、粘膜及基因枪接种实现的保护性免疫
Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11478-82. doi: 10.1073/pnas.90.24.11478.
5
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J Virol. 1995 Apr;69(4):2684-8. doi: 10.1128/JVI.69.4.2684-2688.1995.
6
Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice.核酸疫苗可在无反应小鼠中引发乙型肝炎病毒表面抗原特异性细胞毒性T淋巴细胞。
J Virol. 1995 Oct;69(10):5929-34. doi: 10.1128/JVI.69.10.5929-5934.1995.
7
Identification of serotype-specific and nonserotype-specific B-cell epitopes of coxsackie B virus using synthetic peptides.使用合成肽鉴定柯萨奇B病毒的血清型特异性和非血清型特异性B细胞表位
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8
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