Heremans K, Smeller L
Department of Chemistry, Katholieke Universiteit Leuven, Belgium.
Biochim Biophys Acta. 1998 Aug 18;1386(2):353-70. doi: 10.1016/s0167-4838(98)00102-2.
The effect of pressure on the structure and dynamics of proteins is discussed in the framework of the pressure-temperature stability phase diagram. The elastic (reversible) properties, thermal expansion, compressibility and heat capacity, are correlated with the entropy, volume, and the coupling between entropy and volume fluctuations respectively. The experimental approaches that can be used to measure these quantities are reviewed. The plastic (conformational) changes reflect the changes in these properties in the cold, pressure and heat denaturation.
在压力-温度稳定性相图的框架内讨论了压力对蛋白质结构和动力学的影响。弹性（可逆）性质、热膨胀、压缩性和热容分别与熵、体积以及熵和体积涨落之间的耦合相关。综述了可用于测量这些量的实验方法。塑性（构象）变化反映了在冷变性、压力变性和热变性中这些性质的变化。
