Alstergren P, Ernberg M, Kvarnström M, Kopp S
Department of Clinical Oral Physiology, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
J Oral Maxillofac Surg. 1998 Sep;56(9):1059-65; discussion 1066. doi: 10.1016/s0278-2391(98)90256-7.
The purpose of this study was to investigate whether interleukin-1beta in synovial fluid or blood plasma is involved in the development of pain or hyperalgesia of the temporomandibular joint (TMJ), as well as reduced mandibular mobility and anterior open bite.
Twenty-nine patients with TMJ arthritis and seven healthy subjects were studied. VAS measurement of TMJ tenderness on palpation of the TMJ (TDP), TMJ pressure pain threshold and tolerance level (PPTL), mandibular mobility, pain during joint movements, and degree of anterior open bite (AOB) were assessed. IL-1beta levels were analyzed in TMJ synovial fluid (SF-IL-1beta) and blood samples and correlated with the preceding factors.
SF-IL-1beta showed significant positive correlations with VAS measurement of pain, TDP, and AOB and a negative correlation with PPTL.
This study indicates that IL-1beta in the synovial fluid is associated with pain and hyperalgesia in the TMJ region as well as an anterior open bite. Concerning the latter condition, IL-1beta seems to be a warning signal of tissue destruction.
本研究旨在调查滑液或血浆中的白细胞介素-1β是否参与颞下颌关节（TMJ）疼痛或痛觉过敏的发展，以及下颌运动受限和前牙开颌的发生。
对29例颞下颌关节关节炎患者和7名健康受试者进行了研究。评估了颞下颌关节触诊时的压痛视觉模拟评分（TDP）、颞下颌关节压力疼痛阈值和耐受水平（PPTL）、下颌运动、关节运动时的疼痛以及前牙开颌程度（AOB）。分析了颞下颌关节滑液（SF-IL-1β）和血液样本中的IL-1β水平，并将其与上述因素进行相关性分析。
SF-IL-1β与疼痛的视觉模拟评分、TDP和AOB呈显著正相关，与PPTL呈负相关。
本研究表明，滑液中的IL-1β与颞下颌关节区域的疼痛和痛觉过敏以及前牙开颌有关。关于后一种情况，IL-1β似乎是组织破坏的一个警示信号。
