LMO4的鉴定与特性分析，LMO基因在胚胎发育过程中具有新的表达模式。
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.
作者信息
Kenny D A, Jurata L W, Saga Y, Gill G N
机构信息
Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0650, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11257-62. doi: 10.1073/pnas.95.19.11257.
Abstract
LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors. LMO1, LMO2, and LMO4 have distinct expression patterns in adult tissue, and we demonstrate that nuclear retention of LMO proteins is enhanced by the nuclear LIM interactor (NLI). In situ hybridization to early mouse embryos of 8-14.5 days revealed a complex pattern of LMO4 expression spatially overlapping with NLI and LHX genes. LMO4 expression in somite is repressed in mice mutant for the segment polarity gene Mesp2 and expanded in Splotch mutants. During jaw and limb outgrowth, LMO4 and LMO2 expression define mesenchyme that is uncommitted to regional fates. Although both LMO2 and LMO4 are activated in thymic blast cells, only LMO4 is expressed in mature T cells. Mesenchymal and thymic blast cell expression patterns of LMO4 and LMO2 are consistent with the suggestion that LMO genes inhibit differentiation.
摘要
LMO4是含LIM结构域转录因子中仅含LIM（LMO）亚家族的一个新成员。LMO1、LMO2和LMO4在成体组织中有不同的表达模式，并且我们证明核LIM相互作用分子（NLI）可增强LMO蛋白的核内滞留。对8至14.5天的早期小鼠胚胎进行原位杂交显示，LMO4的表达模式复杂，在空间上与NLI和LHX基因重叠。在节段极性基因Mesp2突变的小鼠中，体节中的LMO4表达受到抑制，而在斑点突变体中则扩大。在颌骨和肢体生长过程中，LMO4和LMO2的表达界定了尚未确定区域命运的间充质。尽管LMO2和LMO4在胸腺母细胞中均被激活，但只有LMO4在成熟T细胞中表达。LMO4和LMO2在间充质和胸腺母细胞中的表达模式与LMO基因抑制分化的观点一致。
相似文献
1
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.LMO4的鉴定与特性分析，LMO基因在胚胎发育过程中具有新的表达模式。
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11257-62. doi: 10.1073/pnas.95.19.11257.
2
Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.FLIN2和FLIN4的设计、生产与特性研究：分子内ldb1:LMO复合物的工程改造
Protein Eng. 2001 Jul;14(7):493-9. doi: 10.1093/protein/14.7.493.
3
Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping.编码仅含LIM结构域蛋白的Lmo4基因的特性分析：基因组结构与比较染色体定位
Mamm Genome. 1999 Nov;10(11):1089-94. doi: 10.1007/s003359901167.
4
Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia.LIM结合蛋白LDB1/NLI1相互作用伙伴编码基因LMO4的鉴定：T细胞急性白血病中LMO蛋白替代的候选基因
Oncogene. 1998 Nov 26;17(21):2799-803. doi: 10.1038/sj.onc.1202502.
5
Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.LMO2和LMO4的N端LIM结构域识别ldb1的结构基础。
EMBO J. 2003 May 1;22(9):2224-33. doi: 10.1093/emboj/cdg196.
6
Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.Lmo4基因的无效突变或Lmo1/Lmo3基因的联合无效突变会导致围产期致死，并且Lmo4控制小鼠的神经管发育。
Mol Cell Biol. 2004 Mar;24(5):2063-73. doi: 10.1128/MCB.24.5.2063-2073.2004.
7
Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators.小鼠变形表皮自调节因子1招募了一个LIM结构域因子LMO-4和CLIM共调节因子。
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15418-23. doi: 10.1073/pnas.95.26.15418.
8
The highly related LIM factors, LMO1, LMO3 and LMO4, play different roles in the regulation of the pituitary glycoprotein hormone alpha-subunit (alpha GSU) gene.高度相关的 LIM 因子 LMO1、LMO3 和 LMO4 在调控垂体糖蛋白激素 α 亚基（alpha GSU）基因方面发挥不同的作用。
Biosci Rep. 2009 Oct 9;30(1):51-8. doi: 10.1042/BSR20090020.
9
LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.LMO4 在发育中的皮质中作为神经基因 2 的共激活因子发挥作用。
Development. 2011 Jul;138(13):2823-32. doi: 10.1242/dev.061879.
10
Differential expression of a transcription regulatory factor, the LIM domain only 4 protein Lmo4, in muscle sensory neurons.一种转录调节因子——仅含LIM结构域4蛋白Lmo4在肌肉感觉神经元中的差异表达。
Development. 2002 Nov;129(21):4879-89. doi: 10.1242/dev.129.21.4879.
引用本文的文献
1
Pro-inflammatory cytokine IL-6 regulates LMO4 expression in psoriatic keratinocytes via AKT/STAT3 pathway.促炎细胞因子白细胞介素-6通过AKT/STAT3信号通路调节银屑病角质形成细胞中LMO4的表达。
Immun Inflamm Dis. 2023 Dec;11(12):e1104. doi: 10.1002/iid3.1104.
2
Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.通过调节 BMP 通路促进斑马鱼内耳和前庭发育。
Genes (Basel). 2023 Jun 28;14(7):1371. doi: 10.3390/genes14071371.
3
How "Neuronal" Are Human Skin Mast Cells?人类皮肤肥大细胞有多“神经元样”？
Int J Mol Sci. 2022 Sep 17;23(18):10871. doi: 10.3390/ijms231810871.
4
GSDMD-mediated pyroptosis: a critical mechanism of diabetic nephropathy.GSDMD 介导的细胞焦亡：糖尿病肾病的关键机制。
Expert Rev Mol Med. 2021 Dec 27;23:e23. doi: 10.1017/erm.2021.27.
5
The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition.PAX-FOXO1s 触发鸡胚神经细胞快速转分化为具有组织侵袭性的肺泡横纹肌肉瘤，其受 S 期进入抑制限制。
PLoS Genet. 2020 Nov 11;16(11):e1009164. doi: 10.1371/journal.pgen.1009164. eCollection 2020 Nov.
6
Periocular neural crest cell differentiation into corneal endothelium is influenced by signals in the nascent corneal environment.眼周神经嵴细胞向角膜内皮的分化受新生角膜环境中信号的影响。
Dev Biol. 2020 Sep 15;465(2):119-129. doi: 10.1016/j.ydbio.2020.06.012. Epub 2020 Jul 19.
7
Incendiary Leptin.致炎瘦素。
Nutrients. 2020 Feb 13;12(2):472. doi: 10.3390/nu12020472.
8
Yeats4 drives ILC lineage commitment via activation of transcription.叶芝 4 通过激活转录来驱动 ILC 谱系的承诺。
J Exp Med. 2019 Nov 4;216(11):2653-2668. doi: 10.1084/jem.20182363. Epub 2019 Aug 21.
9
Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis.Rgma 诱导的 Neo1 蛋白水解促进神经管形态发生。
J Neurosci. 2019 Sep 18;39(38):7465-7484. doi: 10.1523/JNEUROSCI.3262-18.2019. Epub 2019 Aug 9.
10
Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation.Ldb衔接蛋白在皮质脊髓运动神经元分化过程中的代偿作用。
Cereb Cortex. 2017 Feb 1;27(2):1686-1699. doi: 10.1093/cercor/bhw003.
本文引用的文献
1
LIM domains: multiple roles as adapters and functional modifiers in protein interactions.LIM结构域：在蛋白质相互作用中作为衔接子和功能修饰剂的多种作用
Trends Genet. 1998 Apr;14(4):156-62. doi: 10.1016/s0168-9525(98)01424-3.
2
The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.T细胞白血病LIM蛋白Lmo2对成年小鼠的造血作用是必需的。
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3890-5. doi: 10.1073/pnas.95.7.3890.
3
The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.核LIM结构域相互作用蛋白NLI介导LIM结构域转录因子的同源和异源二聚化。
J Biol Chem. 1998 Feb 6;273(6):3152-7. doi: 10.1074/jbc.273.6.3152.
4
Sox10, a novel transcriptional modulator in glial cells.Sox10，一种神经胶质细胞中的新型转录调节因子。
J Neurosci. 1998 Jan 1;18(1):237-50. doi: 10.1523/JNEUROSCI.18-01-00237.1998.
5
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.LIM结构域结合蛋白Ldb1及其伴侣LMO2作为红系分化的负调节因子发挥作用。
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13707-12. doi: 10.1073/pnas.94.25.13707.
6
Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila.Chip是一种广泛表达的染色体蛋白，是果蝇中一个远端翅缘增强子的分割和活性所必需的。
Genes Dev. 1997 Oct 15;11(20):2729-40. doi: 10.1101/gad.11.20.2729.
7
Molecular models for vertebrate limb development.脊椎动物肢体发育的分子模型。
Cell. 1997 Sep 19;90(6):979-90. doi: 10.1016/s0092-8674(00)80364-5.
8
Functional analysis of the nuclear LIM domain interactor NLI.核LIM结构域相互作用蛋白NLI的功能分析
Mol Cell Biol. 1997 Oct;17(10):5688-98. doi: 10.1128/MCB.17.10.5688.
9
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.Mesp2：一种在预分段中胚层表达且对体节起始至关重要的新型小鼠基因。
Genes Dev. 1997 Jul 15;11(14):1827-39. doi: 10.1101/gad.11.14.1827.
10
The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm.与双尾相关的同源异型蛋白Ptx1界定了胚胎的最前端区域，并使后侧中胚层与前侧中胚层区分开来。
Development. 1997 Jul;124(14):2807-17. doi: 10.1242/dev.124.14.2807.
Zotero 插件