Ortiz de Frutos F J, Guerra Tapia A, Gómez de la Cámara A, de la Cruz Bertolo J, Alvarez Fernández J G, de la Mano Orejón D
Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid.
Rev Clin Esp. 1998 Jul;198(7):424-8.
Although there are several diagnostic questionnaires for atopic dermatitis (AD), they have not yet been validated or cannot be used in population studies. Our objective was to validate the questionnaire developed by United Kingdom Working Party's Diagnostic criteria for Atopic Dermatitis (UKWPDCAD).
Validation was developed in two steps: first, the questionnaire was adapted by means of translation and back-translation. Second, validation was conducted with 237 patients referred to the hospital with diagnoses unknown to the investigators. Patients were independently assessed by the investigators who were blinded to the questionnaire.
A total of 102 cases of AD were diagnosed among the 237 patients. The questionnaire showed a sensitivity of 76.5%, with a 95% confidence interval (CI) of 66.8%-84.1%. The specificity was 90.4% (CI = 83.8%-94.6%); the positive predictive value was 85.7% (CI = 76.4%-91.8%), and the negative predictive value 83.6% (CI = 76.3%-89%).
The spanish version of the questionnaire has shown a high diagnostic accuracy, similar to the original written in english. We consider it a useful tool to be used in frequency studies of AD in large general populations.
虽然有几种特应性皮炎（AD）的诊断问卷，但它们尚未经过验证，或无法用于人群研究。我们的目的是验证由英国工作组特应性皮炎诊断标准（UKWPDCAD）制定的问卷。
验证分两步进行：首先，通过翻译和回译对问卷进行改编。其次，对237名因调查人员未知的诊断而转诊至医院的患者进行验证。患者由对问卷不知情的调查人员独立评估。
在237名患者中，共诊断出102例AD。该问卷的敏感性为76.5%，95%置信区间（CI）为66.8%-84.1%。特异性为90.4%（CI = 83.8%-94.6%）；阳性预测值为85.7%（CI = 76.4%-91.8%），阴性预测值为83.6%（CI = 76.3%-89%）。
该问卷的西班牙语版本显示出较高的诊断准确性，与英文原版相似。我们认为它是在大型普通人群中进行AD发病率研究的有用工具。
