异丙肾上腺素对甲基亚硝基脲诱导雌性Wistar大鼠唾液腺和乳腺肿瘤的影响。
The effect of isoprenaline on induction of tumours by methyl nitrosourea in the salivary and mammary glands of female wistar rats.
作者信息
Parkin R, Neale S
出版信息
Br J Cancer. 1976 Oct;34(4):437-43. doi: 10.1038/bjc.1976.189.
Abstract
Pretreatment of rats with isoprenaline sulphate (IPR) stimulated DNA synthesis in both salivary and mammary gland tissues. Salivary gland tumours induced by N-methyl-N-nitrosourea (MNU) were observed for the first time in rats, but occurred only in IPR-pretreated animals given MNU during the period of IPR-stimulated DNA synthesis. The cumulative index of MNU-induced mammary tumours and the number of tumours per tumour-bearing rat were increased by IPR-pretreament only if the animals received MNU during the period of IPR-stimulated DNA synthesis.
摘要
用硫酸异丙肾上腺素（IPR）对大鼠进行预处理可刺激唾液腺和乳腺组织中的DNA合成。首次在大鼠中观察到由N-甲基-N-亚硝基脲（MNU）诱导的唾液腺肿瘤，但仅发生在IPR刺激DNA合成期间给予MNU的IPR预处理动物中。仅当动物在IPR刺激DNA合成期间接受MNU时，IPR预处理才会增加MNU诱导的乳腺肿瘤的累积指数和每只荷瘤大鼠的肿瘤数量。
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