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[海洛因成瘾者的脓疱性念珠菌病]

[Pustular candidiasis in heroin addicts].

作者信息

Leclech C, Cimon B, Chennebault J M, Verret J L

机构信息

Service de Dermatologie. C.H.U. Angers.

出版信息

Ann Dermatol Venereol. 1997;124(2):157-8.

PMID:9740826
Abstract

INTRODUCTION

Pustular candidiasis in heroin addicts is a rare entity in dermatology. We report a case.

CASE REPORT

A 29-year-old female heroin addict developed a painful pustular growth on the scalp. There was no fever. Multiple follicular pustulae measuring 2 to 3 mm were associated with hyperesthesia of the scalp and painful cervical nodes. Biopsy showed acute ostiofolliculitis with a few blastospores and mycelial filaments. Candida albicans was isolated from the pustulae and the buccal cavity. Candida serology was positive (indirect immunofluorescence 1/100, coelectrosyneresis: 4 archs). Search for other localizations and HIV serology were negative. The last injection of brown heroin had been taken 15 days earlier; lemon had been added. Treatment with flucanazole (400 mg/d) led to improvement within 48 hours.

DISCUSSION

Sudden development of pustulae or nodules in pilous zones in a heroin addict should suggest the diagnosis. Outcome depends on early treatment after diagnosis and search for other localizations. Our case presented two particular aspects: ostiofollicular localization of the pustulae and a long delay (15 days) between the (presumably) last injection and the development of the lesion. Folliculitis develops almost exclusively in addicts who use brown heroin. Contamination by Candida albicans results from the lemon used to improve solubility at injection.

摘要

引言

海洛因成瘾者的脓疱性念珠菌病在皮肤科是一种罕见病症。我们报告一例。

病例报告

一名29岁的女性海洛因成瘾者头皮上出现了一个疼痛的脓疱性肿物。无发热症状。多个大小为2至3毫米的毛囊脓疱伴有头皮感觉过敏和颈部疼痛性淋巴结。活检显示为急性毛囊口炎,伴有少量芽生孢子和菌丝。从脓疱和口腔中分离出白色念珠菌。念珠菌血清学呈阳性(间接免疫荧光1/100,协同电泳:4条带)。未发现其他感染部位,HIV血清学检测为阴性。最后一次注射棕色海洛因是在15天前,注射时添加了柠檬。使用氟康唑(400毫克/天)治疗后48小时内病情有所改善。

讨论

海洛因成瘾者毛发部位突然出现脓疱或结节应提示诊断。预后取决于诊断后的早期治疗以及对其他感染部位的排查。我们的病例有两个特殊之处:脓疱的毛囊口部位以及(推测)最后一次注射与病变出现之间有较长的间隔时间(15天)。毛囊炎几乎仅在使用棕色海洛因的成瘾者中发生。白色念珠菌感染是由于注射时用于提高溶解性的柠檬所致。

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