Rijhsinghani A, Yankowitz J, Kanis A B, Mueller G M, Yankowitz D K, Williamson R A
Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242-1080, USA.
Ultrasound Obstet Gynecol. 1998 Aug;12(2):103-6. doi: 10.1046/j.1469-0705.1998.12020103.x.
There are no studies to date on the implications and outcomes of antenatally detected isolated club foot. The purpose of this study was to perform a contemporary evaluation of club foot diagnosed in the antenatal period.
We performed a retrospective analysis of all ultrasound examinations performed in 1989-96 in the Fetal Diagnosis and Treatment Unit of the University of Iowa Hospitals and Clinics (n = 23,863).
All cases of club foot (n = 35) were evaluated for the presence of other detectable abnormalities and karyotype results if available. Postnatal follow-up was performed until over 1 year of age.
We diagnosed unilateral (n = 18) and bilateral (n = 17) club foot from 17.4 to 37.0 weeks. Defects involving other systems were found in 28 of 35 cases. Of the seven cases considered to be isolated antenatally, three were diagnosed with additional malformations in the neonatal period.
Most cases of antenatally diagnosed club foot were not isolated. Even when they were thought to be isolated on antenatal ultrasound, over half of them were later found to be associated with additional severe abnormalities that were detectable only in the neonatal period.
迄今为止，尚无关于产前检测出的孤立性马蹄内翻足的影响及结局的研究。本研究的目的是对产前诊断的马蹄内翻足进行当代评估。
我们对1989 - 1996年间在爱荷华大学医院及诊所胎儿诊断与治疗科进行的所有超声检查（n = 23,863）进行了回顾性分析。
对所有马蹄内翻足病例（n = 35）评估是否存在其他可检测到的异常以及是否有核型结果（若有）。进行产后随访直至1岁以上。
我们在孕17.4至37.0周诊断出单侧（n = 18）和双侧（n = 17）马蹄内翻足。35例中有28例发现涉及其他系统的缺陷。在产前被认为是孤立性的7例中，3例在新生儿期被诊断出有其他畸形。
产前诊断的马蹄内翻足多数并非孤立性。即使在产前超声检查时被认为是孤立性的，其中超过半数后来被发现与仅在新生儿期才可检测到的其他严重异常有关。
