Bosio C M, Orme I M
Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
Infect Immun. 1998 Oct;66(10):5048-51. doi: 10.1128/IAI.66.10.5048-5051.1998.
Vaccination of mice with Mycobacterium bovis culture filtrate proteins (CFP), prepared in a variety of adjuvants (aluminum hydroxide, Quil-A, and dimethyldioctyldecyl ammonium bromide [DDA]), provided significant protection against an aerosol challenge of virulent M. bovis. Additionally, vaccination with CFP in DDA or Quil-A did not sensitize mice to M. bovis purified protein derivative.
用在多种佐剂(氢氧化铝、Quil-A和二甲基二辛基溴化铵 [DDA])中制备的牛分枝杆菌培养滤液蛋白(CFP)对小鼠进行疫苗接种,可提供针对强毒力牛分枝杆菌气溶胶攻击的显著保护。此外,用DDA或Quil-A中的CFP进行疫苗接种不会使小鼠对牛分枝杆菌纯化蛋白衍生物敏感。