Hrnciar J, Katreniaková M, Lepej J, Okapcová J
Interná klinika A a oddelenie nukleárnej medicíny nemocnice F. D. Roosevelta, Banská Bystrica.
Vnitr Lek. 1997 Sep;43(9):562-5.
In insulin resistant subjects with android obesity the leptin levels are, as compared with non-obese subjects, elevated in proportion to their BMI, WHR and their percentage of body fat. Generally independent on obesity, leptin levels are significantly higher in women than in men as in women the percentage of adipose tissue is higher. After administration of 2 mg nicotine in Nicorette chewing gum to 36 android obese non-smokers the elevated baseline values of leptin did not change and thus the observation that cigarettes suppress hunger or that smoking promotes weight reduction is untrue or else this effect is not mediated by nicotine stimulation of leptin secretion or formation in adipose tissue, leptin being the adipose tissue hormone which controls food intake, the sensation of satiety and via neuropeptide Y also other hypothalamic functions such as muscular and sexual activity, gonadoliberin output, thermoregulation etc. Leptin thus offers no alibi to smokers. Conversely smoking in android obese hyperinsulinaemic hyperleptinaemic subjects with syndrome X (5H) potentiates significantly the risk of cardiovascular death.
在患有腹部肥胖的胰岛素抵抗受试者中，与非肥胖受试者相比，瘦素水平随其体重指数（BMI）、腰臀比（WHR）和体脂百分比升高而升高。一般来说，瘦素水平与肥胖无关，但由于女性脂肪组织百分比更高，所以女性的瘦素水平显著高于男性。给36名腹部肥胖的非吸烟受试者服用含2毫克尼古丁的尼古丁咀嚼胶后，瘦素升高的基线值并未改变，因此，香烟抑制饥饿或吸烟促进体重减轻这一观点是错误的，否则这种作用不是由尼古丁刺激脂肪组织中瘦素的分泌或形成介导的，瘦素是一种控制食物摄入、饱腹感的脂肪组织激素，还通过神经肽Y影响其他下丘脑功能，如肌肉和性活动、促性腺激素释放、体温调节等。因此，瘦素不能为吸烟者提供借口。相反，患有X综合征（5H）的腹部肥胖、高胰岛素血症、高瘦素血症受试者吸烟会显著增加心血管死亡风险。
