Goebel R, Khorram-Sefat D, Muckli L, Hacker H, Singer W
Max-Planck-Institut für Hirnforschung, Frankfurt a.M., Germany.
Eur J Neurosci. 1998 May;10(5):1563-73. doi: 10.1046/j.1460-9568.1998.00181.x.
Echoplanar functional magnetic resonance imaging was used to monitor activation changes of brain areas while subjects viewed apparent motion stimuli and while they were engaged in motion imagery. Human cortical areas MT (V5) and MST were the first areas of the 'dorsal' processing stream which responded with a clear increase in signal intensity to apparent motion stimuli as compared with flickering control conditions. Apparent motion of figures defined by illusory contours evoked greater activation in V2 and MT/MST than appropriate control conditions. Several areas of the dorsal pathway (V3A, MT/MST, areas in the inferior and superior parietal lobule) as well as prefrontal areas including FEF and BA 9/46 responded strongly when subjects merely imagined moving stimuli which they had seen several seconds before. The activation during motion imagery increased with the synaptic distance of an area from V1 along the dorsal processing stream. Area MT/MST was selectively activated during motion imagery but not during a static imagery control condition. The comparison between the results obtained with objective motion, apparent motion and imagined motion provides further insights into a complex cortical network of motion-sensitive areas driven by bottom-up and top-down neural processes.
使用回波平面功能磁共振成像来监测受试者观看表观运动刺激以及进行运动想象时脑区的激活变化。人类皮质区MT（V5）和MST是“背侧”处理流的首批区域，与闪烁对照条件相比，它们对表观运动刺激的信号强度有明显增加。由虚幻轮廓定义的图形的表观运动在V2和MT/MST中引起的激活比适当的对照条件更大。当受试者仅仅想象他们几秒钟前看到的运动刺激时，背侧通路的几个区域（V3A、MT/MST、顶叶上下小叶中的区域）以及包括FEF和BA 9/46在内的前额叶区域会有强烈反应。运动想象期间的激活随着一个区域沿背侧处理流与V1的突触距离增加而增加。MT/MST区在运动想象期间被选择性激活，但在静态想象对照条件下未被激活。通过客观运动、表观运动和想象运动获得的结果之间的比较，为一个由自下而上和自上而下神经过程驱动的复杂的运动敏感区域皮质网络提供了进一步的见解。
