Tanda G, Di Chiara G
Department of Toxicology and Consiglio Nazionale delle Ricerche, Centre for Neuropharmacology, University of Cagliari, Italy.
Eur J Neurosci. 1998 Mar;10(3):1179-87. doi: 10.1046/j.1460-9568.1998.00135.x.
The role of mu1 opioid receptors in the stimulation of dopamine transmission in the rat nucleus accumbens by an unusual palatable food (Fonzies) and non-psychostimulant drugs of abuse was investigated by the use of naloxonazine, a pseudo-irreversible antagonist of mu1 opioid receptors. Feeding of Fonzies stimulated dopamine release in the medial prefrontal cortex and in the shell, but not in the core of the nucleus accumbens. Pretreatment with naloxonazine given systemically (15 mg/kg i.p. 20 h before) completely prevented the stimulation of dopamine release in the shell of the nucleus accumbens by Fonzies without affecting that in the prefrontal cortex. Systemic pretreatment with naloxonazine reduced or, depending on the dose, abolished, the stimulation of dopamine release in the nucleus accumbens shell by morphine, nicotine and ethanol, but did not affect that by haloperidol. Naloxonazine also prevented the stimulatory effects of Fonzies, nicotine and morphine on nucleus accumbens dopamine transmission when infused bilaterally in the ventral tegmental area. The results indicate that mu1 opioid receptors in the ventral tegmentum play a major role in the stimulant effects of food and drugs of abuse on mesolimbic dopamine transmission.
通过使用μ1阿片受体的拟不可逆拮抗剂纳洛嗪，研究了μ1阿片受体在一种特殊美味食物（Fonzies）和非精神刺激类滥用药物刺激大鼠伏隔核多巴胺传递中的作用。喂食Fonzies可刺激内侧前额叶皮质和伏隔核壳部的多巴胺释放，但不影响伏隔核核心的多巴胺释放。全身给予纳洛嗪（腹腔注射15mg/kg，提前20小时）预处理可完全阻止Fonzies对伏隔核壳部多巴胺释放的刺激，而不影响前额叶皮质的多巴胺释放。纳洛嗪全身预处理可减少或根据剂量消除吗啡、尼古丁和乙醇对伏隔核壳部多巴胺释放的刺激，但不影响氟哌啶醇对其的刺激。当双侧注入腹侧被盖区时，纳洛嗪也可阻止Fonzies、尼古丁和吗啡对伏隔核多巴胺传递的刺激作用。结果表明，腹侧被盖区的μ1阿片受体在食物和滥用药物对中脑边缘多巴胺传递的刺激作用中起主要作用。
