Peschard S, Carbonnel F, Beaugerie L, D'Almagne Serrano H H, Carrat F, Gendre J P, Cosnes J
Service de Gastroentérologie et de Nutrition, Hôpital Rothschild, Paris.
Gastroenterol Clin Biol. 1998 Jun-Jul;22(6-7):594-600.
To determine the risk and predictive factors for colonic extension in patients with ileal Crohn's disease.
One hundred and fifty patients with ileal Crohn's disease and no specific colonic lesions on initial colonoscopy were studied retrospectively (median follow-up: 51 months).
Twelve patients (8%) developed colonic lesions. Ten-year cumulated risks (95% confidence interval) for colonic extension were 17.2% (range: 5.8-28.6) in the whole group, and 22.4% (range: 8.7-36.1) in the group of 86 patients with repeated colonoscopy. Young age at diagnosis was the only factor predicting colonic extension. Seven patients with colonic extension required immunosuppressive therapy but none underwent surgery.
Ileal Crohn's disease has a low tendency for colonic extension. Colonic extension has no major prognostic implications.
确定回肠克罗恩病患者结肠受累的风险及预测因素。
回顾性研究150例回肠克罗恩病患者，初始结肠镜检查时无特异性结肠病变（中位随访时间：51个月）。
12例患者（8%）出现结肠病变。全组患者结肠受累的10年累积风险（95%置信区间）为17.2%（范围：5.8 - 28.6），86例接受重复结肠镜检查患者的该风险为22.4%（范围：8.7 - 36.1）。诊断时年龄较小是结肠受累的唯一预测因素。7例结肠受累患者需要免疫抑制治疗，但无人接受手术。
回肠克罗恩病结肠受累倾向较低。结肠受累对预后无重大影响。
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