Gong H, Simmons M S, Linn W S, McDonnell W F, Westerdahl D
Department of Medicine, University of Southern California, Los Angeles, USA.
Arch Environ Health. 1998 Sep-Oct;53(5):313-9. doi: 10.1080/00039899809605715.
We hypothesized that acute respiratory responsiveness to ozone predicts chronic lung injury from repeated exposure to ozone-containing air pollution. We tested this hypothesis in 164 middle-aged nonsmoking residents of an ozone-polluted community who underwent lung-function measurements during 1986 and 1987 (i.e., time 3). The time-3 study was a follow up of more comprehensive studies conducted in 1977-1978 (time 1) and in 1982-1983 (time 2). In contrast to the apparent rapid (i.e., approximately 60 ml/y) decline in lung-function measurements between times 1 and 2, our subjects showed little change in forced vital capacity (FVC) or forced expired volume in 1 s (FEV1.0) between times 2 and 3, and they experienced a normal decline between times 1 and 3. A subgroup (n = 45) underwent 2-h laboratory ozone exposures to 0.4 ppm ozone, accompanied by intermittent exercise, and they experienced mild acute reductions in FEV1.0 and FVC, but there was little change in bronchial responsiveness to methacholine. Individual acute responses to laboratory ozone were not correlated with individual long-term changes between times 1 and 3. In summary, the results did not support our initial hypothesis, and they did not confirm rapid function decline in nonsmokers chronically exposed to ozone-containing air pollution.
我们假设，对臭氧的急性呼吸反应性可预测反复暴露于含臭氧空气污染中导致的慢性肺损伤。我们在164名居住在臭氧污染社区的中年不吸烟居民中检验了这一假设，这些居民在1986年和1987年（即时间3）接受了肺功能测量。时间3的研究是对1977 - 1978年（时间1）和1982 - 1983年（时间2）进行的更全面研究的随访。与时间1和时间2之间肺功能测量值明显快速下降（即约60毫升/年）不同，我们的研究对象在时间2和时间3之间用力肺活量（FVC）或1秒用力呼气量（FEV1.0）几乎没有变化，并且他们在时间1和时间3之间经历了正常的下降。一个亚组（n = 45）在实验室中暴露于0.4 ppm臭氧2小时，同时伴有间歇性运动，他们的FEV1.0和FVC出现了轻度急性下降，但对乙酰甲胆碱的支气管反应性几乎没有变化。个体对实验室臭氧的急性反应与时间1和时间3之间的个体长期变化无关。总之，结果不支持我们最初的假设，也未证实长期暴露于含臭氧空气污染中的非吸烟者肺功能会快速下降。
