J Clin Psychiatry. 1998;59 Suppl 12:35-40.
Cognitive deficits are an integral feature of schizophrenia and have a deleterious effect on the ability of schizophrenic patients to work and function in a social environment. Drugs that bring about substantial cognitive improvement represent a major contribution in improving the quality of life in schizophrenia. Recent studies have suggested that the atypical antipsychotics may be more useful than conventional agents for improving cognition. There is evidence that scores on neuropsychological assessments have improved after treatment with clozapine, risperidone, and quetiapine. Future research is needed to characterize and quantify the cognitive effects of the atypical antipsychotics.
认知缺陷是精神分裂症的一个主要特征，对精神分裂症患者在社会环境中工作及正常生活的能力产生有害影响。能带来显著认知改善的药物对提高精神分裂症患者的生活质量有重要作用。最近的研究表明，非典型抗精神病药物在改善认知方面可能比传统药物更有效。有证据显示，使用氯氮平、利培酮和喹硫平治疗后，神经心理学评估得分有所提高。未来的研究需要对非典型抗精神病药物的认知作用进行特征描述和量化。
