植入大鼠腺胃的结肠组织对N-亚硝基-N-甲基脲致癌作用无易感性。
No susceptibility of colon tissue implanted into the glandular stomach of rats to N-nitroso-N-methylurea carcinogenesis.
作者信息
Ando Y, Uesaka T, Kido S, Fujimoto N, Tatematsu M, Ishimura Y, Shiraki K, Hirata S, Kuramoto K, Shoji S, Katoh O, Watanabe H
机构信息
Department of Environment and Mutation, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
出版信息
Oncol Rep. 1998 Nov-Dec;5(6):1373-6. doi: 10.3892/or.5.6.1373.
The present study was undertaken to determine the response of colonic mucosa implanted into the stomach fundus in 6-week-old male F344 rats to oral administration of N-nitroso-N-methylurea (MNU). In graft + MNU, 15% animals had tumors in the implanted colon tissue whereas a 26% incidence of gastric tumors was observed for the pyloric mucosa. In MNU alone, 30% of rats demonstrated gastric tumors. In graft alone 10% of tumors were observed in the grafted site but none in the pylorus. Thus while graft tissue may intrinsically have an elevated risk of tumor development, no susceptibility to MNU was observed in the present study.
本研究旨在确定6周龄雄性F344大鼠胃底植入的结肠黏膜对口服N-亚硝基-N-甲基脲（MNU）的反应。在移植+MNU组中，15%的动物在植入的结肠组织中出现肿瘤，而幽门黏膜的胃肿瘤发生率为26%。仅给予MNU时，30%的大鼠出现胃肿瘤。仅移植组中，10%的肿瘤出现在移植部位，但幽门未出现肿瘤。因此，虽然移植组织本身可能有较高的肿瘤发生风险，但在本研究中未观察到对MNU的易感性。
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