医院住院患者中用于尿路感染的尿试纸筛查结果令人失望。
Disappointing dipstick screening for urinary tract infection in hospital inpatients.
作者信息
Zaman Z, Borremans A, Verhaegen J, Verbist L, Blanckaert N
机构信息
University Hospitals Leuven, Belgium Central Clinical Laboratory, Belgium.
出版信息
J Clin Pathol. 1998 Jun;51(6):471-2. doi: 10.1136/jcp.51.6.471.
AIM
To compare the performance of leucocyte esterase and nitrite dipstick tests with microscopic examination and culture of first morning urines (n = 420) of hospital inpatients.
RESULTS
The sensitivity, specificity, and negative predictive value of the leucocyte esterase test for the cutoff of > 10 WBC/microliter were 57%, 94%, and 68%, respectively. For > 5 WBC per high power field (HPF) these variables were 84%, 90%, and 93%. For > 10(5) colony counts/ml, the sensitivity of the nitrite test was 27%, specificity 94%, and negative predictive value 87%. When either leucocyte esterase or nitrite positivity was accepted as a marker of urinary tract infection, the sensitivity was 78%, specificity 75%, and negative predictive value 94%, and there were 22% false negative results. Semiquantitative microscopic estimation of bacteria per HPF yielded 40% false positives.
CONCLUSIONS
Leucocyte esterase and nitrite dipstick tests are not suitable for screening for urinary tract infections.
目的
比较住院患者首次晨尿（n = 420）的白细胞酯酶和亚硝酸盐试纸条检测与显微镜检查及培养的性能。
结果
白细胞酯酶检测对于白细胞计数>10个/微升的临界值，其敏感性、特异性和阴性预测值分别为57%、94%和68%。对于每高倍视野（HPF）白细胞>5个，这些变量分别为84%、90%和93%。对于菌落计数>10⁵/ml，亚硝酸盐检测的敏感性为27%，特异性为94%，阴性预测值为87%。当白细胞酯酶或亚硝酸盐阳性被视为尿路感染的标志物时，敏感性为78%，特异性为75%，阴性预测值为94%，假阴性结果为22%。每HPF细菌的半定量显微镜估计产生40%的假阳性。
结论
白细胞酯酶和亚硝酸盐试纸条检测不适合用于尿路感染的筛查。
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